What should uterine lining be for implantation

If patients have lower blastocyst rate, we have to see why. Embryology says: if embryos are fragmented, then between day 0 and day 3 it is the problem of an egg. So this is something that we have to work on to improve the blastocyst rate. Sometimes patients work on things very hard, take vitamins, DHA, some of them are even on a growth hormone protocol, but we still do not generate quality eggs that are good enough to develop more blastocysts.

Even though your blastocyst rate is low, you still generate 1 genetically normal and healthy embryo and you still have the same pregnancy rate as everybody else. In order to answer this question I would need to know how old you are. I still believe that when you are older than 35 years old, there is no time anymore for experiments.

That is something nobody knows. We know that results in the blood are not as sensitive as in the lining. We have quite a good study that we use. We have a protocol when patients are putting colony stimulating factors with subcutaneous injections every day in the first week after the transfer. And then twice a week, from the second week until the week 8. The results with recurrent implantation failure are quite promising. So majority of our patients undergo immune modulation with this medication after a couple of unsuccessful transfers.

No, there is not. What we usually do is we monitor the first scan after a patient starts with estrogens day 7 — day 10 of a cycle to see how thick the lining is. There is a formula to follicles that they grow 2 millilitres every 2 days. There is a formula in gynaecology about hCG, the pregnancy test. If hCG doubles every two days, it means that the pregnancy develops correctly. But if we expect endometrium to be seven millimetres on day 7 or day 10 of a cycle, the lining has to grow ,5 millimetre every day.

Yes, it does. What we do is we grow the lining with estrogens. We want the result to be more than 7 milimeters. I know that progesterone will freeze the lining, it will stop the growth. So yes, progesterone will stop the growth of the lining. No, not at all. We do not choose genetically close eggs. The donor has to be matched specifically to certain cases and certain patients. Definitely yes. Secondly: the implantation window biopsy. Thirdly: proper thickness, meaning a proper adjustment of estrogens to your body to achieve lining of more than 7 millimetres.

There are no more secrets. Usually, the receptivity assay is valid for a year. What is changing the receptivity assay results? We have to see if the fibroids have an impact or they do not have an impact. How do I confirm or exclude something in medicine results? I have to work to prove that it is the truth. So, in this case, we have to do hydrosonography.

If we see that fibroids do not have an impact, we do the uterus lining receptivity to see your implantation window and then we transfer. If we see that fibroid has an impact, they have to be surgically removed. This is anatomy. Then there are the embryos, they have to develop to the blastocyst stage.

With the second egg donation, I would test them genetically. Then we have to see if your immunology is average. It means that you either accept HLA of majority donors or we have to match them to you specifically. When blood is too thin, it creates problems. If there are too low platelets, because you have ITP and haematological issues, then we send you to a specialist with blood diseases.

And then we know what to do with you. Then you have to take Heparin until the end of pregnancy. So blood clotting it super easy to confirm or exclude through blood tests.

Sometimes BA embryos look amazing but they are genetically abnormal. Sometimes even genetically normal embryos do not implant because they are too weak to make it through. I would go for one more transfer. With healthy, good quality embryos you have a chance to be pregnant in the next cycle. If somebody has had a miscarriage or if somebody has abnormal uterine bleeding or if embryos are genetically abnormal and we see that we have to terminate the pregnancy, this changes the implantation window.

As I say, through genetic pre-testing of embryos I erase your age. I would like to avoid that because twin pregnancies are always high-risk pregnancies for you. Your cervix can dilate. You can stay in bed till the end of pregnancy and I have to do the C-section. So these are the reasons why we recommend single embryo transfer. Informations published on myIVFanswers. Services provided by myIVFanswers. Necessary cookies are absolutely essential for the website to function properly.

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Contact presenter. Embryo transfer, implantation window, uterine lining guide. Embryo selection — the most sensitive methodology There are different methodologies in the embryo selection process.

Endometrium receptivity window — IVF-Spain According to Dr Szlarb, around the day of a cycle is the moment when the cells of the uterus lining undergo specific changes — the receptors of progesterone are being expressed on the surface of the cells. Embryo transfer, implantation window, uterine lining guide - Questions and Answers. Do you recommend the patient who is over 45 to do PGD testing, even with a high quality blastocyst? Is there a maximum size for endometrium lining? Can it be too thick for embryo transfer?

I am preparing to return frozen embryos from an egg donation. I do not know whether it is worth doing the ER Map test because the embryos were frozen on day 3. Which procedure is the best to guarantee the perfect window of implementation? Is it suggested to remove a fibroid on the lining? How much fibroid has to be removed? Is it fine if it only has small amount of fibroid? When do we need to do the removal of fibroid?

During the embryo transfer cycle or before the transfer cycle? What can be done if even after trying all the mentioned options, a patient shows no significant endometrial development? I have had 2 failed cycles with my own eggs, we are now trying donor eggs. A simple exam using X-ray technology can help a doctor measure the uterine lining. Thin linings are classified as less than or equal to 7mm.

Low estrogen levels and insufficient blood flow are the most common reasons for a thin endometrial lining. Fibroids, abnormal periods, pelvic inflammatory disease, and long-term use of birth control can also affect the lining.

A thick lining also impacts pregnancy. If the lining becomes too thick, endometrial hyperplasia can occur. Several studies have shown a correlation between pregnancy and endometrial thickness.

A healthy uterine lining must be at least 8mm for the effective implementation of a fetus. In contrast, a thick lining should not exceed 12mm wide as this allows for good blood flow. Women have become pregnant in the past with a 7mm lining. However, the right balance significantly increases the chances of a successful pregnancy. A healthy endometrial lining is essential for growing a baby. Women can increase the chances of a healthy lining with some simple lifestyle changes.

Healthy fats and dark leafy greens can help with a healthy lining. Additionally, supplements like iron, fish oil, vitamin E, turmeric, and low-dose aspirin may help. Acupuncture is great for improving circulation and is most effective for months with twice-weekly treatments. Just 30 minutes of physical activity helps the body prepare for pregnancy.

A thin endometrium can result in lower implantation of the embryo. In previous blogs, Katie Koss and Janet Chiarmonte have discussed the various pathologies that can prevent implantation and the three common techniques used to evaluate the uterine cavity. In this blog, the thickness of the endometrial lining and measurement of the lining during cycle monitoring will be discussed. The endometrium responds to estrogen by growth in its glands and the surrounding tissue stroma.

This is reflected on ultrasound by an increase in thickness and formation of a triple-line endometrial pattern. There is no definite cut-off level below which implantation will not occur.

In a recent publication Fertil Steril ; , Dr. Robert Casper from the University of Toronto, Canada offers an interesting mechanism by which a thin lining results in lower implantation. The functional layer of the endometrium has plenty of small blood vessels capillaries , in contrast to the larger spiral arteries in the basal layer.

With ovulation, there is constriction of the spiral arteries with reduced blood flow to the functional layer. This results in reduced oxygen tension, which is good for embryo implantation.