How can oxidative phosphorylation be uncoupled

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Biosensors and Bioelectronics , 91 , If the ATP is not used up quickly, then its concentration slows the action of ATP synthases, which slow the movement of protons out of the intermembrane space.

This buildup of protons will eventually be enough that the free energy needed to transfer a proton into the intermembrane space from the electron transport chain will not be sufficient to overcome the concentration gradient. Electron transport is slowed, and working backwards, the chain reaction slows respiration rates in general.

Thus there is a direct association between respiration rate and physiological energy need. Interestingly, there is an exception to this tight coupling of the electron transport chain and formation of ATP. The purpose of brown fat aka brown adipose tissue , which is most often found in newborn and hibernating mammals, is to generate non-shivering non-movement-based heat to keep the animal warm. Username Please enter your Username.

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Sign in with your library card Please enter your library card number. Related Content Related Overviews thermogenesis brown fat oxidative phosphorylation chemiosmotic theory See all related overviews in Oxford Reference ». Show Summary Details Overview uncoupling protein. UCP Any of a family of proteins that uncouple electron transport from oxidative phosphorylation in mitochondria, so that the energy derived from aerobic tissue respiration is released chiefly as heat instead of being used to make ATP.

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